What do we trade-off for the comfort of technology?

We all go for it - the quick-fix.

But later, we often find that our ignorance has been exploited for the advantage of someone else .. who's only virtue was to get there first.
Evolution has nothing to say about getting there first .. there's nothing there to code in genes.

So .. what I'm asking is - what are we giving up for comfort?

How much comfort is constructive, and at what point is it exploitive at the benefit of comfort for a few, but at the detriment to our species?